Archive ouverte HAL - Diagnostic biologique des angioedèmes bradykiniques : les recommandations du CREAK

Diagnostic biologique des angioedèmes bradykiniques : les recommandations du CREAK

Laurence Bouillet 1 Frederica Defendi 1 Gaëlle Hardy 1 Jean-Yves Cesbron 2, 1, 3 Isabelle Boccon-Gibod 1 Alban Deroux 4, 1 Catherine Mansard 4, 1 David Launay 1 Anne Gompel 5, 1 Bernard Floccard 6, 1 Roland Jaussaud 7, 1 Etienne Beaudouin 8, 1 Guillaume Armengol 9, 1 Yann Olliver 1 Stéphane Gayet 10, 1 Aureli Du Than 1 Laurent Sailler 11, 1 Stéphane Guez 12, 1 Anne Sarrat 12, 1 Lucile Sorin 1 Claire de Moreuil 13, 1 Fabien Pelletier 14, 1 Nicolas Javaud 15, 1 Nicolas Marmion 16, 1 Olivier Fain 17, 1 Julien Faure 18, 1 Chantal Dumestre-Pérard 1, 3
Abstract : Bradykinin mediated angioedema (BK-AE) can be associated either with C1Inhibitor deficiency (hereditary and acquired forms), either with normal C1Inh (hereditary form and drug induced AE as angiotensin converting enzyme inhibitors…). In case of high clinical suspicion of BK-AE, C1Inh exploration must be done at first: C1Inh function and antigenemy as well as C4 concentration. C1Inh deficiency is significant if the tests are below 50 % of the normal values and controlled a second time. In case of C1Inh deficiency, you have to identify hereditary from acquired forms. C1q and anti-C1Inh antibody tests are useful for acquired BK-AE. SERPING1 gene screening must be done if a hereditary angioedema is suspected, even if there is no family context (de novo mutation 15 %). If a hereditary BK-AE with normal C1Inh is suspected, F12 and PLG gene screening is suitable.
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https://hal.archives-ouvertes.fr/hal-02180518
Contributeur : Cordelia Bisanz <>
Soumis le : jeudi 11 juillet 2019 - 14:58:26
Dernière modification le : vendredi 12 juillet 2019 - 08:21:00

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Laurence Bouillet, Frederica Defendi, Gaëlle Hardy, Jean-Yves Cesbron, Isabelle Boccon-Gibod, et al.. Diagnostic biologique des angioedèmes bradykiniques : les recommandations du CREAK. La Presse Médicale, Elsevier Masson, 2019, 48 (1), pp.55-62. ⟨10.1016/j.lpm.2018.06.015⟩. ⟨hal-02180518⟩

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