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Research topics

Cardio-respiratory physiology is the central research field of PRETA which groups physiologists, emergency clinicians and experts in medical device conception and signal processing.

The primary purpose of the team is the development of tools and methods for the extraction of information from physiological and pathophysiological data (models and uses).
The transdisciplinary approach we develop allows us to overcome methodological barriers and to propose innovative preclinical and clinical tools. This strategy is based on both a strong investment in tools and skills in animal experiments experimental platform for small animal surgery, veterinary surgery on large mammals) and physiological investigation on healthy subjects (platform of investigation on healthy volunteers), and the search for additional solutions from the collaboration with different laboratories from other areas of research (physics, chemistry, etc ...).

Finally, PRETA continues to be involved in several basic research projects in different fields of physiology such as nutrition, cardiac ischemia and signal processing.

 

Team strength

 

  • Multidisciplinary team whose research areas lead to transdisciplinary projects
  • Development of tools and methods for extracting physiological information
  • Development of research with a high potential of valorization
  • Strong involvement of team members in teaching
Research Programs
Research Programs

During the evaluated period, the team has been involved in three basic research contracts (2 ANR contracts and 1 European FP7 contract) including 1 as principal investigator (ANR Blanc Sybecar project), 4 applied research projects (1 with the Direction Generale de l’Armement and 3 with the Institut de REcherche sur les Boissons) and 4 projects of valorization and transfer of technology (2 with Grenoble Alpes Valorisation Innovation Technologies, 1 with SATT GIFT and 1 with the Fonds Européen de Développement Régional).

Projet Breath-Diag

Supervisor(s): Raphaël BRIOT
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-15-CE18-0006) - UNIVERSITE GRENOBLE ALPES - [2015-2019]
Fast and sensitive breath analysis for medical diagnostics.

Projet e-SwallHome

Swallowing and Respiration : Modelling and e-Health at Home
Supervisor(s): Pierre-Yves GUMERY
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-13-TECS-0011) - UNIVERSITE GRENOBLE ALPES - [2014-2017]
The project aims to explain the normal behavior of two coupled functions in human, swallowing and breathing, to better understand the etiology of the mechanisms underlying pathological behaviors of dysphagia, dyspnea and dysphonia, related to a brain stroke.
Team members
Presentation of team members (introductory sentence)

Head :

Boucher F. (PU UGA)
Gumery P-Y. (PU UGA)

Permanent staff :

Anglade D. (PH CHUGA)
Briot R. (MCUPH UGA)
Brouta A. (Adj. UGA 80%)
Calabrèse-Vinot P. (MCF UGA)
Debaty G. (PH CHUGA)
Frikha R. (MCF VetAgro Sup)
Fontecave-Jallon J. (MCF UGA)
Loiacono P. (Adj. UGA 10%)
Tanguy S. (MCF UGA)
Thiebault J-J. (MCF VetAgro Sup)

 

2 free collaborators

1 Engineers

3 PhD students

Team coordinator(s)

Permanent members

Others members

PhD students

Platforms - Resources
INTEGRATIVE PHYSIOLOGY

 

Platform for Integrative Physiology Services on Healthy Volunteers

 

Respiratory gas analyzer

P3I

 

P3I

Non-invasive blood pressure monitoring

P3I

ECG and fetal heart sounds

P3I

Electroglottography

P3I

Multi-sensor chest belts

P3I

Inductance breathing apparatus plethysmography

P3I

Pneumotachograph

P3I

Hearth impedance measurement

 

CHUGA

Place : Taillefer building (Site Santé - CHU Grenoble Alpes)

Scientific managers : Julie Fontecave-Jallon and Pascale Calabrese

* Autorisations CPP 15/01/2014 et ANSM 29/01/2014
* Protocole ouvert (MAPO-RCVQ, 2013-A01560-45)

 

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SMALL ANIMAL UNIT

 

Small Animal UNIT

 

  • Experimental surgery
     
  • Cardiovascular monitoring by invasive methods: direct pressure and flow measurements
     
 
  PPA PPA PPA  
 

Cardiovascular monitoring by non-invasive methods with plethysmography (DECRO®).

PPA  

 

Place: Jean Roget building (UGA - Site Santé)

Scientific supervisor: Stéphane Tanguy

 

Primary collaborations and grants
  • Spectrometry laboratory of Joseph Fourier University - Grenoble (LIPhy UMR 5588, CNRS-UJF)

  • Laboratory of Basic and applied Bioenergetics of Joseph Fourier University - Grenoble (INSERM 1055)

  • Department of Physiology – Functional investigations, Raymond Poincaré hospital, AP-HP, Garches

  • Department of Pharmacology, Health Science Centre, University of Debrecen, Hungary

Contact

Address: TIMC-IMAG laboratory, Pavillon TAILLEFER, 38706 LA TRONCHE CEDEX - FRANCE