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Methodological Considerations to Investigate Dosage Parameters of Intensive Upper Limb Rehabilitation in Children with Unilateral Spastic Cerebral Palsy: A Scoping Review of RCTs

Lucas Ravault 1, 2 Nelly Darbois 3 Nicolas Pinsault 1, 2
1 TIMC-ThEMAS - Techniques pour l'Evaluation et la Modélisation des Actions de la Santé
TIMC - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525
Abstract : Purposes: To identify and synthesize RCTs on the isolated effect of dosage parameters of upper limb Intensive Motor Rehabilitation Treatments (IMRT) of children with Unilateral Spastic Cerebral Palsy (USCP); to identify the most frequent methodological weaknesses. Methods: Searches were conducted until September 2018 in gray and published literature databases and supplemented by exploring the identified studies' references. Inclusion criteria applied: RCT; children aged 1.5 to 19 years with USCP; upper limb IMRT differing only from ≥1/4 dosage parameters between groups. Literature analyses conducted: qualitative and descriptive. Results: We identified 461 studies. Seventeen were included: three presented a rehabilitation dosage distinction between groups in Frequency-Time, four in Intensity-Progressivity, three in Intensity-Restraint, two in Intensity-Environment and five presented ≥3 distinctions above. Conclusions: Inconsistencies were noted between USCP lifelong issues, and the short follow-ups and lack of participation assessments. Confounding factors and misstatements in Intent To Treat (ITT) analyses were identified. A meta-analysis was considered irrelevant.
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Soumis le : vendredi 21 août 2020 - 11:08:44
Dernière modification le : mardi 24 novembre 2020 - 16:00:09
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Lucas Ravault, Nelly Darbois, Nicolas Pinsault. Methodological Considerations to Investigate Dosage Parameters of Intensive Upper Limb Rehabilitation in Children with Unilateral Spastic Cerebral Palsy: A Scoping Review of RCTs. Developmental Neurorehabilitation, Informa Healthcare, 2020, 23 (5), pp.309-320. ⟨10.1080/17518423.2019.1687599⟩. ⟨hal-02889431⟩

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