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Force Production by a Bundle of Growing Actin Filaments Is Limited by Its Mechanical Properties

Jean-Louis Martiel 1, 2, * Alphee Michelot 3, 1 Rajaa Boujemaa-Paterski 1, 4 Laurent Blanchoin 1 Julien Berro 5, 1, *
* Auteur correspondant
1 CytoMorphoLab
LPCV - Laboratoire de physiologie cellulaire végétale, LPCV - Laboratoire de physiologie cellulaire végétale, LPCV - Physiologie cellulaire et végétale
2 TIMC-IMAG-DyCTiM - Dynamique Cellulaire et Tissulaire- Interdisciplinarité, Modèles & Microscopies
TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525
Abstract : Bundles of actin filaments are central to a large variety of cellular structures such as filopodia, stress fibers, cytokinetic rings, and focal adhesions. The mechanical properties of these bundles are critical for proper force transmission and force bearing. Previous mathematical modeling efforts have focused on bundles' rigidity and shape. However, it remains unknown how bundle length and buckling are controlled by external physical factors. In this work, we present a biophysical model for dynamic bundles of actin filaments submitted to an external load. In combination with in vitro motility assays of beads coated with formins, our model allowed us to characterize conditions for bead movement and bundle buckling. From the deformation profiles, we determined key biophysical properties of tethered actin bundles such as their rigidity and filament density.
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https://hal.archives-ouvertes.fr/hal-02431736
Contributeur : Jacqueline Martin-Laffon <>
Soumis le : mercredi 8 janvier 2020 - 10:12:36
Dernière modification le : jeudi 26 mars 2020 - 18:57:44

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Jean-Louis Martiel, Alphee Michelot, Rajaa Boujemaa-Paterski, Laurent Blanchoin, Julien Berro. Force Production by a Bundle of Growing Actin Filaments Is Limited by Its Mechanical Properties. Biophysical Journal, Biophysical Society, 2020, 118 (1), pp.182-192. ⟨10.1016/j.bpj.2019.10.039⟩. ⟨hal-02431736⟩

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