Archive ouverte HAL - Systems Biology, Systems Medicine, Systems Pharmacology: The What and The Why

Systems Biology, Systems Medicine, Systems Pharmacology: The What and The Why

Angélique Stéphanou 1 Eric Fanchon 2 Pasquale Innominato 3 Annabelle Ballesta 4
1 TIMC-IMAG-DyCTiM - Dynamique Cellulaire et Tissulaire- Interdisciplinarité, Modèles & Microscopies
TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble
2 TIMC-IMAG-BCM - Biologie Computationnelle et Mathématique
TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble
Abstract : Systems biology is today such a widespread discipline that it becomes difficult to propose a clear definition of what it really is. For some, it remains restricted to the genomic field. For many, it designates the integrated approach or the corpus of computational methods employed to handle the vast amount of biological or medical data and investigate the complexity of the living. Although defining systems biology might be difficult, on the other hand its purpose is clear: systems biology, with its emerging subfields systems medicine and systems pharmacology, clearly aims at making sense of complex observations/experimental and clinical datasets to improve our understanding of diseases and their treatments without putting aside the context in which they appear and develop. In this short review, we aim to specifically focus on these new subfields with the new theoretical tools and approaches that were developed in the context of cancer. Systems pharmacology and medicine now give hope for major improvements in cancer therapy, making personalized medicine closer to reality. As we will see, the current challenge is to be able to improve the clinical practice according to the paradigm shift of systems sciences.
Type de document :
Article dans une revue
Acta Biotheoretica, Springer Verlag, 2018, 66 (4), pp.345-365
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https://hal.archives-ouvertes.fr/hal-01975961
Contributeur : Angélique Stéphanou <>
Soumis le : mercredi 9 janvier 2019 - 16:25:22
Dernière modification le : jeudi 17 janvier 2019 - 13:37:04

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  • HAL Id : hal-01975961, version 1

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Angélique Stéphanou, Eric Fanchon, Pasquale Innominato, Annabelle Ballesta. Systems Biology, Systems Medicine, Systems Pharmacology: The What and The Why. Acta Biotheoretica, Springer Verlag, 2018, 66 (4), pp.345-365. 〈hal-01975961〉

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