Archive ouverte HAL - Antibodies targeting circulating protective molecules in lupus nephritis: Interest as serological biomarkers

Antibodies targeting circulating protective molecules in lupus nephritis: Interest as serological biomarkers

Abstract : Lupus nephritis (LN) is one of the most frequent and severe manifestations of systemic lupus erythematosus (SLE), considered as the major predictor of poor prognosis. An early diagnosis of LN is a real challenge in the management of SLE and has an important implication in guiding treatments. In clinical practice, conventional parameters still lack sensitivity and specificity for detecting ongoing disease activity in lupus kidneys and early relapse of nephritis. LN is characterized by glomerular kidney injury, essentially due to deposition of immune complexes involving autoantibodies against cellular components and circulating proteins. One of the possible mechanisms of induction of autoantibodies in SLE is a defect in apoptotic cells clearance and subsequent release of intracellular autoantigens. Autoantibodies against soluble protective molecules involved in the uptake of dying cells, including complement proteins and pentraxins, have been described. In this review, we present the main autoantibodies found in LN, with a focus on the antibodies against these protective molecules. We also discuss their pathogenic role and conclude with their potential interest as serological biomarkers in LN.
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Autoimmunity Reviews, Elsevier, 2018, 17 (9), pp.890 - 899. 〈10.1016/j.autrev.2018.03.013〉
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http://hal.univ-grenoble-alpes.fr/hal-01865150
Contributeur : Frank Thomas <>
Soumis le : vendredi 31 août 2018 - 08:17:56
Dernière modification le : vendredi 19 octobre 2018 - 01:09:14

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Chantal Dumestre-Pérard, Giovanna Clavarino, Sophie Colliard, Jean-Yves Cesbron, Nicole Thielens. Antibodies targeting circulating protective molecules in lupus nephritis: Interest as serological biomarkers. Autoimmunity Reviews, Elsevier, 2018, 17 (9), pp.890 - 899. 〈10.1016/j.autrev.2018.03.013〉. 〈hal-01865150〉

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