Archive ouverte HAL - Effects of collagen microstructure on the mechanics of the left ventricle.

Effects of collagen microstructure on the mechanics of the left ventricle.

Abstract : The microstructure of the collagen sheath or weave surrounding a myocyte and the collagen struts interconnecting neighboring myocytes is incorporated into a fluid-fiber-collagen continuum description of the myocardium. The sheaths contribute to anisotropic elasticity, whereas the struts contribute to an isotropic component. Elastic moduli of the composite myocyte-sheath complex and the strut matrix are estimated from existing passive biaxial loading data from sheets of canine myocardium. The contribution of the sheath to the elasticity of the myocyte-sheath complex is critically dependent on the helical pitch angle. Calculations for a cylindrical model of the left ventricle using both a fluid-fiber and fluid-fiber-collagen stress tensor show that the collagen strut matrix tends to limit muscle fiber lengthening; increase myocardial tissue pressure during systole, with endocardial tissue pressure exceeding left ventricular pressure; decrease tissue pressure during diastole, and thus facilitate myocardial blood flow; and aid filling during ventricular relaxation by providing a suction effect that relies on a release of stored elastic energy from the previous contraction. Calculations show that this energy is stored mostly in the collagen struts.
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https://hal.archives-ouvertes.fr/hal-00846424
Contributeur : Jacques Ohayon <>
Soumis le : vendredi 19 juillet 2013 - 10:21:46
Dernière modification le : jeudi 21 mars 2019 - 14:56:08

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J. Ohayon, R. S. Chadwick. Effects of collagen microstructure on the mechanics of the left ventricle.. Biophysical Journal, Biophysical Society, 1988, 54 (6), pp.1077-88. ⟨10.1016/S0006-3495(88)83044-3⟩. ⟨hal-00846424⟩

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