Archive ouverte HAL - Phasic regional myocardial inflow and outflow: comparison of theory and experiments.

Phasic regional myocardial inflow and outflow: comparison of theory and experiments.

Abstract : We developed a theory for regional blood flow in the beating heart and validated it with measurements of coronary arterial inflow and venous outflow in the open-chest anesthetized dog. The model used measured aortic, left ventricular, and coronary sinus pressures as input data under control conditions and during long diastoles induced by vagal stimulation. A nonlinear two-compartment lumped model for each transmural layer was obtained by spatial averaging a continuum description of the myocardial microcirculation based on morphometric measurements and appropriate fluid and vascular mechanics principles. The chief results and conclusions of the study are 1) an intramyocardial time constant on the order of 1 s is required to explain the phase opposition between inflow and outflow; 2) capillary and venous perfusion are in phase with arterial pressure, and arterial flow is out of phase with arterial pressure except in superficial intramural layers; 3) subendocardial retrograde systolic flow increases with increased contractility and time constants and decreased arterial pressure; and 4) endocardial capillary and venule volume change by 5.5 and 10%, respectively, during the control cardiac cycle.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-00846421
Contributeur : Jacques Ohayon <>
Soumis le : vendredi 19 juillet 2013 - 10:20:11
Dernière modification le : jeudi 21 mars 2019 - 14:56:08

Identifiants

  • HAL Id : hal-00846421, version 1
  • PUBMED : 2360664

Collections

Citation

R. S. Chadwick, A. Tedgui, J. B. Michel, J. Ohayon, B. I. Levy. Phasic regional myocardial inflow and outflow: comparison of theory and experiments.. American Journal of Physiology, American Physiological Society, 1990, 258 (6 Pt 2), pp.H1687-98. ⟨hal-00846421⟩

Partager

Métriques

Consultations de la notice

88