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Importance of the flow perfusion deficit in the response to captopril in experimental myocardial infarction.

Abstract : Previous results on the effects of angiotensin-converting enzyme (ACE) inhibition in myocardial ischemia are conflicting. To determine whether acute ACE inhibition may influence myocardial perfusion deficit during ischemia and reduce ischemia-reperfusion injury, anesthetized open-chest dogs underwent 2-h left anterior descending coronary artery (LAD) occlusion followed by 6-h reperfusion. After 1-h coronary occlusion, each dog was randomized to receive either captopril [5 mg/kg intravenous (i.v.) bolus and 0.25/kg/h infusion for 7 h] or saline. Whereas arterial pressure was reduced (p = 0.001), captopril did not influence myocardial perfusion deficit: Blood flow in the central ischemic zone represented 17.1 +/- 2.8% of the flow in the nonischemic zone versus 20.5 +/- 3.8% before treatment (NS). The values of the control group were 17.8 +/- 2.5 and 16.7 +/- 2.4%, respectively. In addition, there was no difference in infarct size: 35.9 +/- 3.3% of the area at risk in captopril-treated dogs versus 40.0 +/- 3.6% in controls. Analysis of subgroups based on the level of the collateral flow indicated, however, that ACE inhibition had an adverse effect on infarct size in dogs with high collateral flow: 31.9 +/- 4.6% in captopril dogs versus 17.6 +/- 4.7 (p = 0.048). This effect was related to a decrease in collateral flow because animals exhibiting the highest increase in perfusion deficit presented the greatest increase in infarct size (r = -0.92, p = 0.003). Although in dogs with low collateral flow, ACE inhibition appeared to exert a slight beneficial effect on infarct size, we conclude that at least in this dog model, acute ACE inhibition could exacerbate myocardial injury.
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https://hal.archives-ouvertes.fr/hal-00395772
Contributeur : Michel de Lorgeril <>
Soumis le : mardi 16 juin 2009 - 13:12:15
Dernière modification le : jeudi 21 mars 2019 - 14:56:08

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  • HAL Id : hal-00395772, version 1
  • PUBMED : 1378109

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M. de Lorgeril, M. Ovize, J. Delaye, S. Renaud. Importance of the flow perfusion deficit in the response to captopril in experimental myocardial infarction.. Journal of Cardiovascular Pharmacology, Lippincott, Williams & Wilkins, 1992, 19 (3), pp.324-9. ⟨hal-00395772⟩

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