Fabien
Pierrel

Chercheur
Equipe GEM
[info]
Tél : 04 76 63 74 79
Adresse : Bâtiment Jean Roget, Domaine de la Merci
Bureau : 508E
Mots-clés

microorganismes, métabolisme, bioénergétique, évolution, quinones, ubiquinone, chaines respiratoires

Publications

Liste complète des publications:

http://www.researcherid.com/rid/M-6016-2014

 

Publications sélectionnées :

Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency.

Pierrel F.

Front Physiol. (2017) 8:436                 DOI: 10.3389/fphys.2017.00436

 

Evolution of Ubiquinone Biosynthesis: Multiple Proteobacterial Enzymes with Various Regioselectivities To Catalyze Three Contiguous Aromatic Hydroxylation Reactions

Pelosi L., Ducluzeau A. L., Loiseau L., Barras F., Schneider D., Junier I., Pierrel F.

mSystems (2016) 1: e00091-16               DOI: 10.1128/mSystems.00091-16

 

 

Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast

Payet L. A., Leroux M., Willison J. C., Kihara A., Pelosi L., Pierrel F. 

Cell Chem Biol. (2016) 23: 1241-1250            DOI: 10.1016/j.chembiol.2016.08.008

 

 

Coq6 is Responsible for the C4-Deamination Reaction in Coenzyme Q Biosynthesis in Saccharomyces cerevisiae

Ozeir M., Pelosi L., Ismail A., Mellot-Draznieks C., Fontecave M., Pierrel F.

J Biol Chem (2015) 290:24140-24151                DOI: 10.1074/jbc.M115.675744

 

ubiI, a New Gene in Escherichia coli Coenzyme Q Biosynthesis, Is Involved in Aerobic C5-hydroxylation

Hajj Chehade M., Loiseau L., Lombard M., Pecqueur L., Ismail A., Smadja M., Golinelli-Pimpaneau B., Mellot-Draznieks C., Hamelin O., Aussel L., Kieffer-Jaquinod S., Labessan N., Barras F., Fontecave M., Pierrel F.

J Biol Chem (2013) 288: 20085-92                DOI: 10.1074/jbc.M113.480368

 

Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogues rescue Coq6 deficiency

Ozeir M., Mühlenhoff U., Webert H., Lill R., Fontecave M. and Pierrel F.

Chem Biol (2011) 18: 1134-1142               DOI: 10.1016/j.chembiol.2011.07.008


 

Partenariats

Collaborations actives:

Marc Fontecave (Collège de France, Paris)

Frédéric Barras (Institut Pasteur, Paris)

Léonardo Salviati (Université de Padova, Italie)

Martin Ott (Stockholm University, Suède)