Archive ouverte HAL - Ultraviolet–visible–near-infrared optical properties of amyloid fibrils shed light on amyloidogenesis

Ultraviolet–visible–near-infrared optical properties of amyloid fibrils shed light on amyloidogenesis

Abstract : Amyloid fibres attract considerable interest due to their biological role in neurodegenerative diseases and their potential as functional biomaterials. Here, we describe an intrinsic signal of amyloid fibres in the near-infrared range. When combined with their recently reported blue luminescence, it paves the way towards new blueprints for the label-free detection of amyloid deposits in in vitro and in vivo contexts. The blue luminescence allows for staining-free characterization of amyloid deposits in human samples. The near-infrared signal offers promising prospects for innovative diagnostic strategies for neurodegenerative diseases—to improve medical care and for the development of new therapies. As a proof of concept, we demonstrate direct detection of amyloid deposits within brains of living, aged mice with Alzheimer’s disease using non-invasive and contrast-agent-free imaging. Ultraviolet–visible–near-infrared optical properties of amyloids open new research avenues for amyloidosis as well as for next-generation biophotonic devices.
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https://hal.archives-ouvertes.fr/hal-02181640
Contributeur : Yves Usson <>
Soumis le : vendredi 12 juillet 2019 - 11:46:18
Dernière modification le : lundi 16 septembre 2019 - 17:12:23

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Jonathan Pansieri, Véronique Josserand, Sun-Jae Lee, Anäelle Rongier, Daniel Imbert, et al.. Ultraviolet–visible–near-infrared optical properties of amyloid fibrils shed light on amyloidogenesis. Nature Photonics, Nature Publishing Group, 2019, 13 (7), pp.473-479. ⟨10.1038/s41566-019-0422-6⟩. ⟨hal-02181640⟩

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