Fabien
Pierrel

Chercheur
Team GEM
[info]
Phone: 04 76 63 74 79
Address: Bâtiment Jean Roget, Domaine de la Merci
Office: 508E
Keywords

microorganisms, metabolism, bioenergetics, evolution, quinones, ubiquinone, respiratory chaines

Publications

Complete list of publications:

http://www.researcherid.com/rid/M-6016-2014

 

Selected Publications:

 

Ubiquinone Biosynthesis over the Entire O2 Range: Characterization of a Conserved O2-Independent Pathway

Pelosi, L., Vo, C. D., Abby, S. S., Loiseau, L., Rascalou, B., Hajj Chehade, M., Faivre, B., Gousse, M., Chenal, C., Touati, N., Binet, L., Cornu, D., Fyfe, C. D., Fontecave, M., Barras, F., Lombard, M.*, Pierrel, F*.

mBio (2019) 10: e01319-19        

DOI: 10.1128/mBio.01319-19

               

A soluble metabolon synthesizes the isoprenoid lipid Ubiquinone

Hajj Chehade, M., Pelosi, L., Fyfe, C., Loiseau, L., Rascalou, B., Brugiere, S., Kazemzadeh, K., Vo, T. D., Ciccone, L., Aussel, L., Coute, Y., Fontecave, M., Barras, F., Lombard, M. & Pierrel, F. *

Cell Chemical Biology (2019) 26:482-492

DOI: 10.1016/j.chembiol.2018.12.001

 

Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency.

Pierrel F.*

Front Physiol. (2017) 8:436

DOI: 10.3389/fphys.2017.00436

 

Evolution of Ubiquinone Biosynthesis: Multiple Proteobacterial Enzymes with Various Regioselectivities To Catalyze Three Contiguous Aromatic Hydroxylation Reactions

Pelosi L., Ducluzeau A. L., Loiseau L., Barras F., Schneider D., Junier I., Pierrel F.*

mSystems (2016) 1: e00091-16

DOI: 10.1128/mSystems.00091-16

 

Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast

Payet L. A., Leroux M., Willison J. C., Kihara A., Pelosi L., Pierrel F. *

Cell Chemical Biology (2016) 23: 1241-1250

DOI: 10.1016/j.chembiol.2016.08.008

 

Partnerships

Active collaborations:

Marc Fontecave (Collège de France, Paris)

Frédéric Barras (Institut Pasteur, Paris)

Axel Magalon (LCB, Marseille)

Barbara Schoepp-Cothenet (BIP, Marseille)

Leonardo Salviati (Padova University, Italie)

Martin Ott (Stockholm University, Suède)