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Introduction team

We are studying Toxoplasma gondii, an obligate intracellular parasite, which is both an important opportunistic pathogen and a model for the cell biology of related parasites in the Apicomplexa phylum. The strategy we developed to study gene(s) and pathway(s) controlling the resistance to toxoplasmosis has been recently expanded to other pathologies, tularemia and Crohn disease. In all cases, the susceptibility vs resistance is dependent on both pathogen and host determinants.

Scientific theme and general objectives

The team Natural Barrier and Infectivity is interested in survival adaptation and pathogenesis of intracellular pathogens. Indeed, during evolution, the selection pressure exerted by pathogens has led to the diversification of complementary immune responses. Conversely, pathogens have evolved various means of evading or subverting host defenses. Innate immunity, the evolutionarily older defence system, provides immediate protection from infection. It refers to the first line of defence against pathogens and includes muco-cutaneous barriers, the complement system and involves various types of cells such as macrophages. Innate immunity involves pathogen- recognition systems, and the diversification of responses relies, together with environmental factors, on the combined genetic diversity of both host and pathogen. Using relevant experimental models of infection, our team aims to identify these genetic factors and understand their role in the modulation of innate immune response and consequently, in the outcome of infection. The results of these models can then be applied to the human pathology by comparative and functional genomics. In terms of public health, the identification of genes and pathways involved in these diseases would open the way for the development of new pharmacological tools. In addition, knowledge of allelic variations is important for understanding the process of co- evolution and their impact on medicine (predictive value, personalized medicine).

Research topics

We are studying Toxoplasma gondii, an obligate intracellular parasite, which is both an important opportunistic pathogen and a model for the cell biology of related parasites in the Apicomplexa phylum. The strategy we developed to study gene(s) and pathway(s) controlling the resistance to toxoplasmosis has been recently expanded to other pathologies, tularemia and Crohn disease. In all cases, the susceptibility vs resistance is dependent on both pathogen and host determinants.

Research Programs
Research Programs

 

 

Team members
Presentation of team members (introductory sentence)

Geographical address

BNI team
TIMC-IMAG, Bâtiment Jean Roget, 5ème étage
Facultés de Médecine et Pharmacie
Place du Commandant Nal
F-38700 La Tronche
France
 

 

mailing address

Equipe Barrières Naturelles et Infectiosité - BNI
TIMC-IMAG (UMR5525 Université Grenoble Alpes - CNRS)
Institut Jean Roget
BP 170
38042 Grenoble cedex 9

 

Team coordinator(s)

Permanent members

Others members

Primary collaborations and grants
  • Nicolas Blanchard (Inserm, Toulouse),
  • Maryse Lebrun (Université de Montpellier, CNRSUMR 5235)
  • Rima McLeod (Université de Chicago),
  • GIMAP (Université de Lyon, St-Etienne),
  • Financements publics :
  • LabEx ParaFrap (http://www.labex-parafrap.fr/fr/)
  • Programme ANR Blanc “Host and parasite pathways controlling exogenous MHC I antigen presentation during Toxoplasma gondii infection”,
  • Programme ANR Emergence “Development of immuno-enzymatic assays for the detection of the circulatory antigens GRA1 and GRA2 from Toxoplasma gondii”,
  • DRCI “Dosage de l’   expression de GADD34 dans la polyarthrite rhumatoïde” (CHU Grenoble),
  • Cluster 10 “Mechanism of membrane tubulation within the Toxoplasma vacuole” (Région Rhône-alpes),
  • Programme ANR MIME “Identification du (des) gène(s) du locus de Toxo1, qui contrôle(nt) l’   issue de l’   infection par Toxoplasma gondii chez le rat ».
  • Financements privés :
  • GRAIN-GRAVIT « rGRAs antigens and serodiagnosis »,
  • Royal Canin « Drug assays ».

Contact

Address: Faculté de Médecine de Grenoble, Bâtiment Jean Roget, 38 706 La Tronche