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Scientific theme and general objectives

Data science and modeling for living systems and healthcare

The team develops fundamental approaches and new mathematical and physical models for the analysis and interpretation of biological data, particularly those derived from high-throughput technologies. It builds models describing the evolutionary emergence of genetic differences between populations, the architecture or dynamics of biological interaction networks, the regulation and organization of chromatin, the quality control of data issued from high-throughput platforms as well as the risk associated with false discovery. The developed methods are based in particular on Bayesian methods, logical inference or on numerical simulations.

The team also analyzes epidemiological and demographic data from surveys, cohorts, cancer registries and other public databases. It develops methods of statistical modeling in clinical or population epidemiology and in public health, for the assessment of risks to populations or the estimation of over-diagnosis.

Research topics

  • Data Science

  • Computational Biology

  • Bioinformatics

  • Physical and Mathematical Modeling

  • Omics Data

  • Systems Biology

Research Programs
Research Programs

Research contracts:

Contrat FRM

Supervisor(s): Nicolas THIERRY MIEG
Contract: FONDATION POUR LA RECHERCHE MEDICALE - CNRS - [2015-2018]

Projet AfriCrop

Supervisor(s): Olivier FRANCOIS
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-13-BSV7-0017) - CNRS - [2014-2018]
Documenting African Crop Domestication.
Project Page

Analyse des données Isère du Registre du Cancer

Supervisor(s): Patrice FRANCOIS
Contract: Association Registre du Cancer de l'Isère - Financement de thèse - UNIVERSITE GRENOBLE ALPES - [2015-2017]

EpiDevoMath

Supervisor(s): Daniel JOST
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-15-CE12-0006) - CNRS - [2016-2018]
Epigenetic regulation of development: towards a predictive mathematical modeling of three dimensional genome folding and cellular memory.
Project Page

Convention INSERM

Supervisor(s): Daniel JOST
Contract: Convention INSERM - UNIVERSITE GRENOBLE ALPES - [2015-2018]
Discovery and modeling of Epigenetically regulated genomic domains in lung cancer.

FRM

Supervisor(s): Daniel JOST
Contract: FONDATION POUR LA RECHERCHE MEDICALE - CNRS - [2016-2019]

MAS Flagella

Supervisor(s): Nicolas THIERRY MIEG
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-14-CE15-0002) - CNRS - [2014-2019]
Genetics and Pathophysiology of Morphological Abnormalities of the Sperm Flagellum associated with human male infertility. Morphological Abnormalities of Sperm Flagella: MAS Flagella.
Project Page

Registre Cancer Isère

Supervisor(s): Patrice FRANCOIS
Contract: Association Registre du Cancer de l'Isère - Financement de thèse - UNIVERSITE GRENOBLE ALPES - [2015-2017]
Team members
Presentation of team members (introductory sentence)

The team brings together PhD students, post-docs, researchers, professors and medical doctors around the data science and modeling for living systems and healthcare:

Team coordinator(s)

Permanent members

Others members

PhD students

Anciens membres de l'equipe

Alumni

Alumni


 Achard, Vérane
 Amblard, Cécile
 Ben Amor, Eddy
 Berro, Julien
 Blum, Michaël (DR CNRS actuellement en dispo chez OWKIN)
 Carvunis, Anne-Ruxandra (co-encadrement avec Dr. M. Vidal, DFCI, Boston)
 Caye, Kevin
 Csilléry, Katalin
 Corblin, Fabien
 Deist, Timo
 Dias Alves, Thomas
 Douzal, Ahlame
 Duforet-Frebourg, Nicolas
 Durand, Eric
 Elena, Adrien
 Emily, Mathieu
 Frambourg, Cédric
 Forest, Loic
 Frichot, Eric
 Hajj Hassan, Ali
 Houssein, Sahal
 Jay, Flora
 Karaouzene, Thomas
 Kulkarni, Om
 Linge, Yanis
 Luu, Keurcien
 Martiel, Jean-Louis
 Mobilia, Nicolas
 Robelin, David
 Rolland, Jéremy
 Sambourg, Laure
 Schoville, Sean
 Sjöstrand, Agnes

Thesis

The PhD thesis in progress in our team:

  • Alexandre Bellier : "Les compétences relationnelles en consultation médicale : évaluation et développement pour la qualité des soins " (framed by José Labarere , CHAFFANJON Philippe )
  • Clémentine Decamps : "Hétérogénéité et stochasticité cellulaire dans les tissus sains et tumoraux. " (framed by JOST Daniel , Magali Richard )
  • Clément Gain : "Apprentissage profond pour évaluer la vulnérabilité génomique des populations face aux changements environnementaux. " (framed by Olivier Francois )
  • Basile Jumentier : "Analyse de la médiation des effets d'expositions environnementales sur la santé de l'enfant. " (framed by Olivier Francois , LEPEULE Johanna )
  • Kapil Newar : "Modeling the information transfer between metabolism and epigenetics " (framed by Eric Fanchon , Daniel JOST )
Platforms - Resources
PACKAGES AND SOFTWARES DEVELOPED BY BCM TEAM
 

 https://github.com/bcm-uga    

 

 

 

 

 

 plateforme BCM

 

    

 

Contact

Nicolas.Thierry-Mieg@univ-grenoble-alpes.fr
Phone: 04 56 52 00 67
Address: TIMC-IMAG laboratory, BCM team, Pavillon TAILLEFER, 38700 LA TRONCHE - FRANCE