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Scientific theme and general objectives

Data science and modeling for living systems and healthcare

The team develops fundamental approaches and new mathematical and physical models for the analysis and interpretation of biological data, particularly those derived from high-throughput technologies. It builds models describing the evolutionary emergence of genetic differences between populations, the architecture or dynamics of biological interaction networks, the regulation and organization of chromatin, the quality control of data issued from high-throughput platforms as well as the risk associated with false discovery. The developed methods are based in particular on Bayesian methods, logical inference or on numerical simulations.

The team also analyzes epidemiological and demographic data from surveys, cohorts, cancer registries and other public databases. It develops methods of statistical modeling in clinical or population epidemiology and in public health, for the assessment of risks to populations or the estimation of over-diagnosis.

Research topics

  • Data Science

  • Computational Biology

  • Bioinformatics

  • Physical and Mathematical Modeling

  • Omics Data

  • Systems Biology

Research Programs
Research Programs

Research contracts:

Contrat FRM

Supervisor(s): Nicolas THIERRY MIEG
Contract: FONDATION POUR LA RECHERCHE MEDICALE - CNRS - [2015-2018]

Projet AfriCrop

Supervisor(s): Olivier FRANCOIS
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-13-BSV7-0017) - CNRS - [2014-2018]
Documenting African Crop Domestication.
Project Page

Analyse des données Isère du Registre du Cancer

Supervisor(s): Patrice FRANCOIS
Contract: Association Registre du Cancer de l'Isère - Financement de thèse - UNIVERSITE GRENOBLE ALPES - [2015-2017]

Projet AGIR

Supervisor(s): Michael BLUM
Contract: Université Joseph Fourier, Grenoble Innovation Recherche - UNIVERSITE GRENOBLE ALPES - [2014]
Machine learning for personalized medicine : genotype imputation using fused lasso.

FROGH

Supervisor(s): Michael BLUM
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-16-CE12-0033) - CNRS - [2016-2020]
Genetic study of the French population.
Project Page

EpiDevoMath

Supervisor(s): Daniel JOST
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-15-CE12-0006) - CNRS - [2016-2018]
Epigenetic regulation of development: towards a predictive mathematical modeling of three dimensional genome folding and cellular memory.
Project Page

Convention INSERM

Supervisor(s): Daniel JOST
Contract: Convention INSERM - UNIVERSITE GRENOBLE ALPES - [2015-2018]
Discovery and modeling of Epigenetically regulated genomic domains in lung cancer.

FRM

Supervisor(s): Daniel JOST
Contract: FONDATION POUR LA RECHERCHE MEDICALE - CNRS - [2016-2019]

MAS Flagella

Supervisor(s): Nicolas THIERRY MIEG
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-14-CE15-0002) - CNRS - [2014-2019]
Genetics and Pathophysiology of Morphological Abnormalities of the Sperm Flagellum associated with human male infertility. Morphological Abnormalities of Sperm Flagella: MAS Flagella.
Project Page

AGRHUM

Supervisor(s): Michael BLUM
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-14-CE02-0003) - CNRS - [2014-2018]
Evaluating mechanisms of genetic adaptation to rapid environmental changes: agriculture and the human model.
Project Page

Projet INTERCROSSING - Overheads

EU-funded Marie Curie Initial Training Network
Supervisor(s): Michael BLUM
Contract: Europe - UNIVERSITE GRENOBLE ALPES
Inotive Training Environment for Reseachers Combining the Resources of Statical Science, Informatics and Genetics.
Project Page

Registre Cancer Isère

Supervisor(s): Patrice FRANCOIS
Contract: Association Registre du Cancer de l'Isère - Financement de thèse - UNIVERSITE GRENOBLE ALPES - [2015-2017]

AGIR 2014 (PACK2)

Supervisor(s): Sophie PARK
Contract: Université Joseph Fourier, Grenoble Innovation Recherche - UNIVERSITE GRENOBLE ALPES - [1970-1970]
Team members
Presentation of team members (introductory sentence)

The team brings together PhD students, post-docs, researchers, professors and medical doctors around the data science and modeling for living systems and healthcare:

Team coordinator(s)

Permanent members

Others members

PhD students

Anciens membres de l'equipe

Alumni

- Achard, Vérane
- Amblard, Cécile
- Ben Amor, Eddy
- Berro, Julien
- Csilléry, Katalin
- Carvunis, Anne-Ruxandra (co-encadrement avec Dr. M. Vidal, DFCI, Boston)
- Corblin, Fabien
- Deist, Timo
- Douzal, Ahlame
- Duforet-Frebourg, Nicolas
- Durand, Eric
- Elena, Adrien
- Emily, Mathieu
- Frambourg, Cédric
- Forest, Loic
- Frichot, Eric
- Hajj Hassan, Ali
- Houssein, Sahal
- Jay, Flora
- Linge, Yanis
- Martiel, Jean-Louis
- Mobilia, Nicolas
- Robelin, David
- Rolland, Jéremy
- Sambourg, Laure
- Schoville, Sean
- Sjöstrand, Agnes

Thesis

The PhD thesis in progress in our team:

Platforms - Resources
PACKAGES AND SOFTWARES DEVELOPED BY BCM TEAM
 

 https://github.com/bcm-uga    

 

 

 

 

 

 plateforme BCM

 

    

 

Contact

michael.blum@univ-grenoble-alpes.fr
Phone: 04 56 52 00 65
Address: TIMC-IMAG laboratory, BCM team, Pavillon TAILLEFER, IN3S, 38706 LA TRONCHE CEDEX - FRANCE