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Anaïs Gagnieu (TIMC) // March. 15 2019 - 2pm // Pavillon Taillefer R32
Modeling mechanical cell substrate interactions for cell movement.
Physical environmental factors play an important role in many biological processes such as embryogenesis, wound healing, tumor invasion and connective tissue morphogenesis. It is well known that in all these processes, cells interact with their substrate via traction forces; much less is known about the role of substrate deformation on cell behavior. Here, we propose a model to study cell - substrate interactions where 1) the cells apply forces as they move, thus deforming the substrate and 2) in return these deformations play a role in cell movement.
We will show some preliminary results illustrating the influence of this biomechanical coupling on cell motion.
Seminars take place every Friday, at 2pm (30 minutes talks - 30 minutes discussion).