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Jose Labarere (TIMC-IMAG) // July 5 2019 - 2pm // Pavillon Taillefer R32

Flow cytometric analysis of neutrophil myeloperoxidase expression in peripheral blood for ruling out myelodysplastic syndromes. A diagnostic accuracy study

Suspicion of myelodysplastic syndromes is one of the commonest reasons for bone marrow aspirate in elderly patients presenting with persistent peripheral blood cytopenia of unclear etiology. A peripheral blood assay that accurately rules out myelodysplastic syndromes would have major benefits. The diagnostic accuracy of the intraindividual robust coefficient of variation for neutrophil myeloperoxidase expression measured by flow cytometric analysis in peripheral blood was evaluated in a retrospective derivation study (44 myelodysplastic syndrome cases and 44 controls) and a prospective validation study (68 consecutive patients with suspected myelodysplastic syndromes). Compared with controls, myelodysplastic syndrome cases had higher median robust coefficient of variation values for neutrophil myeloperoxidase expression (40.2% versus 30.9%, P<.001). The area under the receiver operating characteristic curve estimates were 0.94 (95% confidence interval [CI], 0.86-0.97) and 0.87 (95% CI, 0.76-0.94) in the derivation and validation studies, respectively. A robust coefficient of variation lower than 30% ruled out myelodysplastic syndromes with 100% sensitivity (95% CI, 78-100%) and 100% negative predictive value (95% CI, 83%-100%) in the prospective validation study. Neutrophil myeloperoxidase expression measured by flow cytometric analysis in peripheral blood might obviate the need for invasive bone marrow aspirate and biopsy for up to 29% of patients with suspected myelodysplastic syndromes.

Seminars take place every Friday, at 2pm (30 minutes talks - 30 minutes discussion).



  When? Where? Who?   What?
October 12/10/2018 R32 Daniel Jost TIMC-IMAG Understanding heterochromatin 3D reorganization during senescence
  19/10/2018 R32 Florian Privé TIMC-IMAG Make your slides with Rmarkdown
  26/10/2018 R32 Raphael Bacher DATA Institute Don't know what to choose between R and Python ? Try Julia
November 02/11/2018 R32 OFF   Toussaint
  09/11/2018 R32 Eric Fanchon TIMC-IMAG Reachability Analysis applied to Iron Homeostasis
  16/11/2018 R32 OFF   Anniversaire TIMC
  23/11/2018 R32 Clémentine Décamps TIMC-IMAG PenDA: a rank based method for Personalized Differential Analysis
  30/11/2018 R32 Thomas Burger CEA PEPA test: fast and powerful differential analysis from relative quantitative proteomics data using shared peptides
December 07/12/2018 R32 Samuel Bernard INRIA Dracula Integrative approaches to model circadian clock control of cell population growth
  14/12/2018 R32 OFF   Data challenge @ Aussois
  21/12/2018 R32 OFF    
  28/12/2018 R32 OFF   Christmas
January 04/01/2019 R32 OFF   Christmas
  11/01/2019 R32 Serkan Apaydın INRIA (Sophia Anti.) Deep learning applications in drug discovery and protein structure analysis
  18/01/2019 R32 Hervé Seligmann Jerusalem New analyses for molecular sequence data
  25/01/2019 R32 Maxime Folschette LS2N (Nantes) Bioinformatics methods for system biology
February 01/02/2019 R32 Olivier François TIMC-IMAG Deep urn models: The rich get richer (and richer)
  08/02/2019 R32 Kapil Newar TIMC-IMAG Epigenetic model of histone modifications
  15/02/2019 IAB Anaïs Bardet

ESBS (Strasbourg)

Transcription factor sensitivity to DNA methylation
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March 01/03/2019 R32 OFF    
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  15/03/2019 R32 Anaïs Gagnieu TIMC-IMAG Modeling mechanical interactions cell substrate for cell movement
  22/03/2019 R32 Antoine Frenoy Institut Pasteur Inferring ecological lifestyles of bacterial species from metahenomic datasets: application to horizontal transfer and virulence
  29/03/2019 R32 Clémentine Décamps TIMC-IMAG HADACA project: organisation of a data challenge about cancer heterogeneity deconvolution
April 05/04/2019 R32 Tomas Alarcon CRM (Barcelona) Heterogeneity in epigenetic regulatory systems: epigenetic plasticity in aging and cancer
  12/04/2019 R32 Basile Jumentier TIMC-IMAG Sparse lfmm, a new sparse regression for genetic or epigenetic association studies
  19/04/2019 R32 Nicolas Glade TIMC-IMAG Computing the structural and behavioral complexities and distances in threshold Boolean networks.
  26/04/2019 R32 Cancelled    
May 03/05/2019 R32 Laurent Guyon CEA Interpretation of microRNA datasets with network based approaches
  10/05/2019 R32 Cancelled    
  17/05/2019 R32 Michael Blum TIMC-IMAG An overview of challenges and opportunities for polygenic risk scores
  24/05/2019 R32 Sophie Abby TIMC-IMAG Evolution playing a molecular buiding set: the case of bacterial protein secretion systems
  31/05/2019 R32 OFF   WE Ascension
June 07/06/2019 R32 Nicolas Thierry-Mieg TIMC-IMAG JC: Calling low-VAF somatic variants with Needlestack in multi-sample NGS data
  14/06/2019 R32 MISE AU VERT    
  21/06/2019 R32 Pierre Jacquet TIMC-IMAG How the cancer cells adapts its energy metabolism: some new insights from a computational model
  28/06/2019 R32 Arnaud Seigneurin   Modeling the benefits and risks of a population-based breast cancer screening program
July 05/07/2019 R32 José Labarère TIMC-IMAG Flow cytometric analysis of neutrophil myeloperoxidase expression in peripheral blood for ruling out myelodysplastic syndromes. A diagnostic accuracy study.
  12/07/2019 R32 free