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Cell discrete modeling: coupling architecture and chimics
Dynamical processes in the cell are intesely studied but the emergence of new properties at the cell level raises a double question: how the architecture of the cell controls the gene activation and the protein synthesis? How the activity of proteins might generate mechanical forces, which modify the cyto-skeleton rigidity and, finally, the cell architecture? To address these questions, we propose a modeling approach combining an intuitive 3D description of the cell morphology and the generation of movements in agreement with the physics or the chemistry of the cell.
Publication : Promayon, E., Martiel, J.-L., Tracqui, P., Physically-based 3D simulations of cell deformations and migrations, Polymer and cell dynamics - multiscale modeling and numerical simulations, Ed. Alt, W.; Chaplain, M.; Griebel, M.; Lenz, J., Birkhäuser-Verlag, pp125-138, 2003.
Collaborations : Other TIMC laboratory teams (TIMB and Dynacell)
Status : in development
Contact : Emmanuel.Promayon@imag.fr