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MRI/histology registration.Application to prostate cancer
Histology is the gold standard for cancer diagnosis, grading and localization. We have developed the ProPath system enabling 3D reconstruction of a model from histologic slices and registration to MRI data. The clinical application is prostate cancer. Reconstruction is based on the Stanford protocol. Registration is a 3D/3D elastic surface registration. One objective is a better understanding of MRI visualisation of cancers. A longer term objective is to build a statistical map of prostate cancer occurrence in the different anatomical zones of the prostate in order to assist biopsy planning.
Reference: Bart S., Mozer P., Hemar P., Lenaour G., Comperat E., Renard-Penna R., Chartier-Kastler E., Troccaz J. MRI-histology registration in prostate cancer. In Proceedings of Surgetica’2005, Merloz P., Troccaz J. (Eds), Sauramps Medical, 2005, pp361-367 (PDF)
Collaborations: La Pitié Salpétrière Hospital, Paris (Dr Bart, Dr Mozer, Dr Chartier-Kastler – urology dept –anatomopathology dept – imaging dept)
Status: pre-study on cadaver prostates then on patients treated by radical prostatectomy. This project is funded by PHRC national 2003 « Prostate-Echo »